Complexation of fluoroquinolones with magnesium ions
نویسندگان
چکیده
Aim. To evaluate strength of magnesium ion complexes with levofloxacin and moxifloxacin. Materials methods . Complexation levofloxacin, moxifloxacin, reference ligands (ethylenediaminetetraacetate (EDTA), sodium citrate, glycine) ions in the range from 0.0 to 1.0 mmol / l was studied. The technique developed by authors (patent RU 2680519 C1) used measure rate a model formation reaction phosphate coarse dispersion. Complexing activity expressed relation EDTA compared theoretical exchange equilibrium constants. half maximal effective concentration (C50) calculated Michaelis − Menten equation dependence complexing on dose. Results. A correlation between EDTA, citrate ions, glycine constants (R = −0.87, p < 0.001) found. In 0.4 l, both moxifloxacin showed lesser effect than (p 0.001), 0.6 their comparable > 0.050). fluoroquinolones did not differ at any 0.050), but C50 (0.13 l; 95% confidence interval (CI) 0.11–0.15) significantly lower that (0.22 CI 0.19–0.26), 0.001). Within 0.4–1.0 range, higher within 0.2–1.0 it Conclusion. proposed method close exceeded glycine. complexation may be associated ability induce side effects deficiency.
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ژورنال
عنوان ژورنال: Bûlleten' Sibirskoj Mediciny
سال: 2022
ISSN: ['1819-3684', '1682-0363']
DOI: https://doi.org/10.20538/1682-0363-2022-3-6-12